Blood test for
T-Cell Response to COVID19

We have a new blood test available at My Specialist GP for patients wishing to check their T-Cell response to COVID-19. In response to the COVID virus your body can produce B-cell antibodies or T-Cell antibodies.

This test is called the Covid T-Spot test.

Until recently only a B-cell response could be tested by PCR or lateral flow testing.

This new test from a UKAS registered lab in Oxford, can additionally confirm if you have a T-cell antibody response.

There are 4 reasons a patient might consider having this test:

  • A previous low response of B-Cell antibody - either post Vaccine or post COVID (which would have been revealed by a blood test)

  • Assist with decision making of whether to have further vaccinations 

  • Surprisingly tested negative on PCR and lateral flow when in contact with COVID positive family or friends

The results from the test are either Reactive (positive) or Non-Reactive (negative). Currently this test cannot give a level of response. 

Included in the cost of this test is an optional phone consultation with one of our GP’s to discuss the result/ implication.

Frequently asked questions

When should I use the T-SPOT.COVID test?

The T-SPOT.COVID test should be used to detect a cell mediated immune response to SARS-CoV-2. The test is intended to identify those individuals who are capable of generating an immune response to SARS-CoV-2, even if serologically negative.

What is the accuracy of the test?

The data from the US clinical study shows an average percent positive agreement between the T-SPOT.COVID test and PCR of 96.6 % (84/87) at <60 days after positive PCR result, and 83.3% (40/48) at >60 days after positive PCR result. An overall negative agreement of 98.0 % (98/100) was seen in a cohort of individuals presumed negative (low risk of infection and no previous PCR positive result) but living in an endemic region

What does a positive T-SPOT.COVID test result mean?

A positive test result means that a patient has T cells that are reactive to the SARS-CoV-2 specific peptides used in the T-SPOT.COVID test. It is highly likely that they have been exposed to the SARSCoV-2 virus.

What does a negative test result mean?

A negative test result means that the patient does not have T cells that are reactive to the SARS-CoV2 specific peptides used in the test. It is therefore unlikely that they have been exposed to the SARSCoV-2 virus


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Blood test